| # | Children | Name | Born | Died | Father | Mother |
|---|
| 1 | | | b. Abt 1745 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 2 | | | b. 1755 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 3 | | | b. 9 May 1757 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 4 | | | b. Abt 1758 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 5 | | | b. Abt 1761 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 6 | | | b. Abt 1762 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 7 | | | b. 1763 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 8 | | | b. 1764 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 9 | | | b. Abt 1768 | d. Aft 1791 | Richard Edmund Knowles, Sr. | Patience Prettyman |
| 10 | | | b. Abt 1771 | d. Yes, date unknown | Richard Edmund Knowles, Sr. | Patience Prettyman |
- 1754