| # | Children | Name | Born | Died | Father | Mother |
| 1 | | | b. 11 Jan 1817 | d. Abt 1863 | William H. Francis, Sr. | Elizabeth "Betsy" Roberts |
| 2 | Yes | | b. 1822 | d. Aft 1870 | William H. Francis, Sr. | Elizabeth "Betsy" Roberts |
| 3 | Yes | | b. 1828 | d. Aft 1860 | William H. Francis, Sr. | Elizabeth "Betsy" Roberts |
| 4 | | | b. 1833 | d. Aft 1850 | William H. Francis, Sr. | Delilah Gibson Quillen, (Cherokee) |
| 5 | | | b. 1836 | d. Aft 1850 | William H. Francis, Sr. | Delilah Gibson Quillen, (Cherokee) |
| 6 | | | b. Abt 1838 | d. Aft 1860 | William H. Francis, Sr. | Delilah Gibson Quillen, (Cherokee) |
| 7 | | | b. 24 Sep 1841 | d. 14 Jan 1924 | William H. Francis, Sr. | Delilah Gibson Quillen, (Cherokee) |
| 8 | | | b. Abt 1843 | d. Aft 1870 | William H. Francis, Sr. | Delilah Gibson Quillen, (Cherokee) |