| # | Children | Name | Born | Died | Father | Mother |
|---|
| 1 | Yes | | b. Between 1771 and 1780 | d. Aft 1840 | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 2 | | | b. 1777 | d. 1840 | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 3 | | | b. 1783 | d. Aft 1919 | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 4 | Yes | | b. Between 1776 and 1795 | d. Aft 1820 | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 5 | | | b. 1802 | d. 1881 | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 6 | | | | | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 7 | | | | | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 8 | | | | | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 9 | | | | | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 10 | Yes | | b. 4 Mar 1791 | d. 20 Mar 1858 | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
| 11 | | | | | Isaiah Weatherly, Sr. | Mrs. Nancy (..) Weatherly |
- Aft 1828